TANSHINONE IIA - AN OVERVIEW

The large GTPase dynamin is important for clathrin-dependent coated-vesicle development. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was uncovered in a display screen of ~sixteen,000 compounds for inhibitors of the dynamin2 GTPase.While frequently